1·They might like to ponder the kind of European issue big enough to win votes, continent-wide.
但如果他们面临在整个大陆这样的范围内如何赢得选举这样的大事，他们也会深思熟虑一番的。
2·Because I grew up in a dysfunctional family, anger is a big issue for me.
我是在一个不正常的家庭里长大的，所以乱发脾气是我的一大问题。
—— 《牛津词典》
3·This is a big issue ; we need more time to think about it.
这是个重大问题，我们需要花较多的时间考虑。
—— 《牛津词典》
4·When you want to study ancient human and Neanderthal remains, there's a big issue of contamination with contemporary human DNA.
当你想要研究古人类和尼安德特人的遗骸，一个大问题是当代人类的 DNA 受到的污染。
5·Switzerland has already chosen one version of this approach by forcing its two big banks to issue new contingent convertible (CoCo) bonds.
瑞士已经采取了类似的做法，规定其两家大银行发行新的或有可转换（CoCo）债券。
6·This is going to be the next big environmental issue after climate change.
这将是继气候变化之后的下一个重大环境问题。
7·The new ultra-low emission zone (Ulez) is likely to be a big issue in next year's mayoral election.
“超低排放新区（Ulez）”很可能是明年伦敦市长选举的重大议题。
8·The next big issue confronting the workers is the question of wages.
摆在工人面前的第二大问题是工资问题。
9·The big issue with these systems is scalability: it is not easy to add extra processors.
这些系统的一个大问题是可伸缩能力：不容易添加其他处理器。
10·Time management is a big issue.
时间管理就是一个大问题。